Exemestane is an aromatase inhibitor that plays a crucial role in the treatment of hormone-sensitive breast cancer, particularly in postmenopausal women. The drug’s primary function is to inhibit the aromatase enzyme, which is responsible for converting androgens into estrogens. By blocking this conversion, exemestane effectively lowers estrogen levels in the body, which is vital since many breast tumors are driven by this hormone.
Exemestane is an aromatase inhibitor used in the treatment of breast cancer. It works by reducing the production of estrogen in the body, which can help slow or stop the growth of certain types of breast tumors that require estrogen to grow. To learn more about Exemestane side effects, visit Exemestane side effects.
Mechanism of Action
The mechanism of action of exemestane involves:
- Inhibition of aromatase enzyme activity.
- Reduction of circulating estrogen levels.
- Decreased estrogenic stimulation of breast cancer cells.
Clinical Uses
Exemestane is typically utilized in the following clinical scenarios:
- Adjuvant therapy for early-stage hormone receptor-positive breast cancer.
- Treatment of advanced breast cancer that has progressed after tamoxifen therapy.
Potential Side Effects
While exemestane is effective, it may also cause some side effects, including but not limited to:
- Hot flashes.
- Joint pain or stiffness.
- Fatigue.
- Nausea.
In conclusion, exemestane remains a vital component in the management of estrogen-sensitive breast cancer, providing an alternative for patients who cannot tolerate other forms of hormonal therapy. Its ability to lower estrogen levels directly impacts tumor growth and progression, making it an essential tool in oncology.